California reports first U.S. case of Clade I Mpox variant. (Image: Wikimedia Commons) 
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Clade I Mpox Hits U.S. for the First Time: California Reports Case

CDC Confirms First U.S. Case of Clade I Mpox in California, Raising Concerns Amid Global Spread; Health Experts Urge Precaution and Preventive Measures for Public Safety

Dr Sreelekshmi P

California has recently confirmed the first U.S. case of clade I mpox, a more aggressive strain of the virus that is sparking fresh global concerns. The Centers for Disease Control and Prevention (CDC) reported the diagnosis, though it reassured the public that the overall risk remains low.

What is Mpox?

Mpox, previously called monkeypox, is a viral infection that shares similarities with the now-eradicated smallpox virus.

The disease can spread through direct contact such as touching, kissing, or sexual activity, as well as through contaminated items like clothing, bedding, and needles, as noted by the World Health Organization (WHO).

The onset of mpox typically starts with flu-like symptoms, including fever, chills, fatigue, headache, and muscle aches.

The onset of mpox typically starts with flu-like symptoms, including fever, chills, fatigue, headache, and muscle aches. (Image: Pixabay)
These symptoms are often followed by a rash, which turns into raised, itchy lesions that eventually scab over and heal over the course of several weeks.
Mpox typically presents with a rash, which turns into raised, itchy lesions that eventually scab over and heal over the course of several weeks. (Image: Wikimedia Commons)

Patient Treated and Isolating at Home

The patient, who had recently traveled from Eastern Africa, where a widespread outbreak of mpox is ongoing, received treatment at a local medical facility before being released. The individual is currently staying at home in isolation, with their condition showing signs of improvement.

Clade I: More Severe, But Less Deadly in Recent Outbreaks

Historically, clade I mpox has been known for causing more severe illness, with death rates ranging from 3%-11%. However, new data suggests that in the current outbreak, with proper medical care, death rates have dropped to as low as 1%. This trend is expected to continue, especially in countries with robust healthcare systems like the United States.

Global Spread: Mpox Clade Ib Gains Ground

Although clade II has been active in the U.S. since last year's outbreaks, the more alarming clade I strain is now drawing global attention. The subvariant clade Ib, which has been spreading rapidly in countries like Germany, India, and the UK, has shown relatively mild disease courses, with no deaths reported so far.

WHO’s Upcoming Meeting to Assess Public Health Concern

According to the World Health Organization (WHO), cases have surged in several African countries, including the Democratic Republic of Congo, Burundi, and Uganda. A meeting scheduled for November 22 will discuss whether the current outbreak still qualifies as a public health emergency of international concern.

How to Protect Yourself from Mpox

The CDC continues to stress prevention measures, including avoiding close contact with infected individuals and contaminated materials like clothing, bedding, and sex toys. Vaccination is recommended for those eligible, with two doses offering protection.

Stay Informed, Stay Safe

As the situation evolves, health authorities urge everyone to stay informed and take precautions to reduce the risk of infection.

Note: This content is purely informational and isn’t medical guidance. It shouldn’t replace professional medical counsel. Always consult your physician regarding treatment risks and benefits.

(Input from various sources)

(Rehash/Dr. Sreelekshmi P/MSM)

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