It seems that microplastics, defined as plastic particles smaller than 5 millimeters. (Representational image: Unsplash) 
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Study Reveals Microplastics May Travel from Gut to Brain

The study, published in Environmental Health Perspectives, delved into the journey of microplastics through the bodies of mice

Susmita Bhandary

A recent study conducted by researchers at the University of New Mexico sheds light on just how far microplastics can travel and the potential impact they may have on our health.

The study, published in Environmental Health Perspectives, delved into the journey of microplastics through the bodies of mice, mimicking human exposure levels. They discovered some concerning findings, such as that, after ingestion, microplastics didn't just stay in the gut but also spread to vital organs like the liver, kidneys, and yes, even the brain.

But how do these tiny particles manage to infiltrate our bodies so thoroughly? It seems that microplastics, defined as plastic particles smaller than 5 millimeters, have become common in our environment, from soil to food to water. Once ingested, they can move through the gut barrier and migrate to distant organs because of their minute size.

The study's lead author, Marcus Garcia, PharmD, explained, "Our findings suggest that microplastic exposure can lead to metabolic changes in these tissues, indicating potential systemic effects. The implications of our findings for human health are substantial."

Our findings suggest that microplastic exposure can lead to metabolic changes in these tissues, indicating potential systemic effects
Marcus Garcia, PharmD, Postdoctoral Fellow at the University of New Mexico College of Pharmacy

The more concerning fact is that the type and amount of microplastics ingested can influence the extent of their impact. In the study, mice were exposed to different amounts of polystyrene or mixed polymer microspheres, with researchers finding microplastics in multiple organs after ingestion. Moreover, specific metabolic changes were observed in the colon, liver, and brain, depending on the type and concentration of microplastics.

The mice were exposed to different amounts of polystyrene or mixed polymer microspheres. (Representational image: Wikimedia Commons)

Dr. Heather Leslie, an independent scientist specializing in microplastics, emphasized the significance of the study's findings, noting that laboratory-dosed microplastics were not only absorbed after ingestion but also deposited in organs. This mirrors what happens with "wild" microplastics found in our living environment.

That is significant because once in place, common microplastic types can start interfering with the biology, as the metabolomics work in the same study showed for multiple organs
Dr. Heather Leslie, Independent Scientist Specializing in Analyzing Microplastics and Additives

While the study provides crucial insights, it's essential to acknowledge its limitations. Conducted on mice, further research is needed to confirm whether these findings translate to humans. Additionally, the study focused on microplastics without chemical additives, leaving questions about the potential impact of additives unanswered.

Nevertheless, the implications for human health are profound. With estimates suggesting that the average person ingests 5 grams of microplastic particles each week, it is clear that action is required. As Dr. Tracey Woodruff from the University of California, San Francisco, emphasizes, lawmakers must act immediately to prevent further human exposure to microplastics.

In the meantime, there are steps individuals can take to reduce their risk of exposure, from opting for plastic-free goods to choosing minimally processed foods and filtered water. However, the overall message is that microplastics are infiltrating our bodies, and we need to understand their impact better to protect our health.

The study underscores the widespread nature of microplastics and their potential to influence metabolic pathways and organ function. With further research, we can hope to mitigate the impact of these tiny yet concerning pollutants on human health.

(Input from various media sources)

(Rehash/Susmita Bhandary/MSM)

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