Yale Cancer Center: CAR T-cell Therapy & Stem Cell Transplantation Reaccredited

Yale Cancer Center and Smilow Cancer Hospital have again received an internationally recognized accreditation for cellular therapy and stem cell transplantation from FACT.
Yale Cancer Center and Smilow Cancer Hospital have again received an internationally recognized accreditation for cellular therapy and stem cell transplantation from FACT.
(Representative image: Unsplash)
Yale Cancer Center and Smilow Cancer Hospital have again received an internationally recognized accreditation for cellular therapy and stem cell transplantation from FACT. (Representative image: Unsplash)
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Yale Cancer Center (YCC) and Smilow Cancer Hospital (SCH) have again received an internationally recognized accreditation for cellular therapy and stem cell transplantation from the Foundation for the Accreditation of Cellular Therapy (FACT), giving patients life-saving cancer treatment options in Connecticut. SCH is the only cancer hospital in the state offering these lifesaving therapies, including chimeric antigen receptor (CAR) T-cell therapy. A new cellular therapy, tumor infiltrating lymphocyte (TIL) therapy, will be available soon for melanoma.

“FACT accreditation has evolved into a necessary qualification to be accepted and competitive in the field of cellular therapy. This accreditation shows that we strive to achieve the highest quality care for cellular therapy treatment programs.”

Stuart Seropian, MD, Clinical Director and Lead Physician of the Stem Cell Transplant Program at YCC and SCH

YCC and SCH uphold the most rigorous standards in every aspect of transplantation and cellular therapy – from clinical care to donor management, cell collection, processing, storage, transportation, administration, and cell release. There are currently 310 FACT-accredited institutions worldwide.

What are cellular therapies?

SCH is one of a select group of hospitals and cancer centers that offer CAR T-cell therapy (a type of immune effector cell therapy) to patients with solid tumors, relapsed/refractory melanoma, and even disease areas beyond oncology.

CAR T-cell therapy is a relatively new and highly personalized type of immunotherapy drug that uses a patient’s synthetically modified T cells — a type of white blood cell — to kill cancer cells.

"CAR T is an exciting new form of immunotherapy that is proving effective in patients with certain recurrent or resistant blood cancers.”
Stuart Seropian, MD, Clinical Director and Lead Physician of the Stem Cell Transplant Program at YCC and SCH

YCC and SCH will soon offer (TIL) therapy cellular therapy for melanoma that was recently approved by the Food and Drug Administration. Doctors grow a large number of tumor infiltrating lymphocyte cells in the lab from a sample of a patient’s own tumor and return the cells to the body to seek out and combat tumors.

Doctors grow a large number of tumor infiltrating lymphocyte cells in the lab from a sample of a patient’s own tumor and return the cells to the body to seek out and combat tumors. (Representative image: Unsplash)
Doctors grow a large number of tumor infiltrating lymphocyte cells in the lab from a sample of a patient’s own tumor and return the cells to the body to seek out and combat tumors. (Representative image: Unsplash)

What is stem cell transplantation?

A stem cell transplant, which is also known as a bone marrow transplant, is a medical procedure in which healthy stem cells from a donor replace damaged or diseased bone marrow. The healthy stem cells can then develop into new, healthy bone marrow and blood cells. The procedure can be used to treat various cancers of the blood, bone marrow, or lymph system such as leukemia or lymphoma.

YCC physicians at SCH offer transplantation, using compatible donor stem cells, which is known as an allogeneic transplant or using a patient’s own stem cells, which is known as an autogulous transplant.

The procedure can be used to treat various cancers of the blood, bone marrow, or lymph system such as leukemia or lymphoma.
(Representative image: Unsplash)
The procedure can be used to treat various cancers of the blood, bone marrow, or lymph system such as leukemia or lymphoma. (Representative image: Unsplash)

A leader in cellular therapy and stem cell transplant

The stem cell transplant program at YCC and Smilow first received FACT accreditation in 2003, and reaccreditation occurs every three years.

YCC and SCH are members of the National Marrow Donor Program. This program tracks data on patients who have received a transplant at accredited United States Transplant Centers. Data from the program shows that after one year, patients who receive a stem cell transplant at Smilow Cancer Hospital have a 9 percent higher expected one year survival rate than the national rate of 63%.

Smilow also ranks as a top hospital in U.S. News & World Report as one of the "America's Best Hospitals" for leukemia, lymphoma, and myeloma — three conditions for which CAR T-cell therapy and stem cell transplants may be necessary.

(NewsWise/YVH)

Yale Cancer Center and Smilow Cancer Hospital have again received an internationally recognized accreditation for cellular therapy and stem cell transplantation from FACT.
(Representative image: Unsplash)
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