Findings from a new study suggest that taking a probiotic could help prevent the decline in memory and thinking that can accompany aging. This research may pave the way for new, non-invasive treatments that leverage the gut microbiome to mitigate cognitive decline in the aging population.
The researchers found that when study participants with mild cognitive impairment received the probiotic Lactobacillus rhamnosus GG (LGG) for three months, their cognitive scores increased. This cognitive improvement was also associated with changes in their gut microbiome.
Aljumaah, who is also affiliated with King Saud University in Saudi Arabia, will present the findings at NUTRITION 2023, the annual flagship meeting of the American Society for Nutrition held July 22-25 in Boston.
“Many studies focus on severe forms of cognitive diseases such as Alzheimer's and dementia, but these conditions are more advanced, making them significantly harder to reverse or treat. In contrast, we focused on mild cognitive impairment, which can include problems with memory, language, or judgment. Interventions at this stage of cognitive impairment could slow down or prevent the progression to more severe forms of dementia.”
Mashael Aljumaah, a microbiology doctoral candidate at the University of North Carolina at Chapel Hill and North Carolina State University.
The study involved 169 participants between 52 and 75 years old who were divided into two groups depending on whether they had no neurological issues or mild cognitive impairment. Within each group, participants either received the LGG probiotic or a placebo in a double-blind, randomized clinical trial lasting three months. The researchers selected the LGG probiotic because prior research had shown its potential beneficial effects in animal models.
To investigate the study participants’ gut microbiomes, the researchers used 16S rRNA gene sequencing to identify and compare bacteria present in stool samples. They then used whole genome sequencing to gain insights into the functional roles of the bacteria identified.
For study participants who had mild cognitive impairment and received the LGG probiotics, the Prevotella relative abundance decreased. This change coincided with improved cognitive scores, suggesting that cognitive health in older adults could be improved by manipulating the gut microbiota.
“By identifying specific shifts in the gut microbiome associated with mild cognitive impairment, we're exploring a new frontier in preventive strategies in cognitive health,” said Aljumaah. “If these findings are replicated in future studies, it suggests the feasibility of using gut microbiome-targeted strategies as a novel approach to support cognitive health.”
The researchers are now working to understand the specific mechanisms of how microbes like Prevotella influence the gut in a way that improves brain health. Specifically, they are exploring how certain molecules produced by these bacteria modulate the functionality of neuroprotective hormones that can cross the blood-brain barrier. (Newswise/SS)
